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ENZYME entry: EC 1.14.14.56

Accepted Name
1,8-cineole 2-exo-monooxygenase.
Alternative Name(s)
CYP3A4.
Reaction catalysed
1,8-cineole + [reduced NADPH--hemoprotein reductase] + O(2) <=> 2-exo-hydroxy-1,8-cineole + [oxidized NADPH--hemoprotein reductase] + H(2)O
Cofactor(s)
Heme-thiolate.
Comment(s)
  • The mammalian enzyme, expressed in liver microsomes, performs a variety of oxidation reactions of structurally unrelated compounds, including stereoids, fatty acids, and xenobiotics.
  • Cf. EC 1.14.14.55, EC 1.14.14.57 and EC 1.14.14.73.
  • Formerly EC 1.14.13.157.
Cross-references
BRENDA1.14.14.56
EC2PDB1.14.14.56
ExplorEnz1.14.14.56
PRIAM enzyme-specific profiles1.14.14.56
KEGG Ligand Database for Enzyme Nomenclature1.14.14.56
IUBMB Enzyme Nomenclature1.14.14.56
IntEnz1.14.14.56
MEDLINEFind literature relating to 1.14.14.56
MetaCyc1.14.14.56
UniProtKB/Swiss-Prot
P08684, CP3A4_HUMAN

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