ID   1.14.14.57
DE   taurochenodeoxycholate 6alpha-hydroxylase.
AN   CYP3A4.
AN   CYP4A21.
AN   taurochenodeoxycholate 6alpha-monooxygenase.
CA   (1) taurochenodeoxycholate + reduced [NADPH--hemoprotein reductase] +
CA   O2 = taurohyocholate + oxidized [NADPH--hemoprotein reductase] + H2O +
CA   H(+).
CA   (2) lithocholate + reduced [NADPH--hemoprotein reductase] + O2 =
CA   hyodeoxycholate + oxidized [NADPH--hemoprotein reductase] + H2O + H(+).
CC   -!- Requires cytochrome b5 for maximal activity.
CC   -!- Acts on taurochenodeoxycholate, taurodeoxycholate and less readily on
CC       lithocholate and chenodeoxycholate.
CC   -!- In adult pig (Sus scrofa), hyocholic acid replaces cholic acid as a
CC       primary bile acid.
CC   -!- Formerly EC 1.14.13.97.
DR   Q9GJX5, CP4AL_PIG  ;
//