ID   1.14.14.73
DE   albendazole monooxygenase (sufoxide-forming).
AN   albendazole hydroxylase.
AN   albendazole sulfoxidase.
AN   CYP1A2.
AN   CYP2J2.
AN   CYP3A4.
CA   (1) albendazole + reduced [NADPH--hemoprotein reductase] + O2 =
CA   albendazole S-oxide + oxidized [NADPH--hemoprotein reductase] + H2O +
CA   H(+).
CA   (2) fenbendazole + reduced [NADPH--hemoprotein reductase] + O2 =
CA   fenbendazole S-oxide + oxidized [NADPH--hemoprotein reductase] + H2O +
CA   H(+).
CC   -!- This is one of the activities carried out by some microsomal
CC       cytochrome P450 monooxygenases.
CC   -!- A similar conversion is also carried out by a different microsomal
CC       enzyme (EC 1.14.13.32), but it is estimated that cytochrome P450s are
CC       responsible for 70% of the activity.
DR   P51589, CP2J2_HUMAN;  P08684, CP3A4_HUMAN;
//