ID   1.14.14.75
DE   fenbendazole monooxygenase (4'-hydroxylating).
AN   CYP2C19.
CA   fenbendazole + reduced [NADPH--hemoprotein reductase] + O2 =
CA   4'-hydroxyfenbendazole + oxidized [NADPH--hemoprotein reductase] + H2O +
CA   H(+).
CC   -!- CYP2C19 is microsomal cytochrome P450 monooxygenase that catalyzes
CC       the hydroxylation of the benzene ring of fenbendazole, a broad-
CC       spectrum anthelmintic used against gastrointestinal nematodes and the
CC       larval stages of cestodes.
CC   -!- This activity is also carried out by CYP2J2. cf. EC 1.14.14.74.
CC   -!- CYP2C19 does not act on albendazole.
DR   P33261, CP2CJ_HUMAN;
//