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ENZYME entry: EC 1.14.14.88

Accepted Name
Isoflavone 3'-hydroxylase.
Alternative Name(s)
CYP81E9.
Reaction catalysed
Formononetin + [reduced NADPH--hemoprotein reductase] + O(2) <=> calycosin + [oxidized NADPH--hemoprotein reductase] + H(2)O
Cofactor(s)
Heme-thiolate.
Comment(s)
  • A cytochrome P450 (heme-thiolate) protein.
  • Also acts on biochanin A and other isoflavones with a 4'-methoxy group.
  • Involved in the biosynthesis of the pterocarpin phytoalexins medicarpin and maackiain.
  • Formerly EC 1.14.13.52.
Cross-references
PROSITEPDOC00081
BRENDA1.14.14.88
EC2PDB1.14.14.88
ExplorEnz1.14.14.88
PRIAM enzyme-specific profiles1.14.14.88
KEGG Ligand Database for Enzyme Nomenclature1.14.14.88
IUBMB Enzyme Nomenclature1.14.14.88
IntEnz1.14.14.88
MEDLINEFind literature relating to 1.14.14.88
MetaCyc1.14.14.88
Rhea expert-curated reactions1.14.14.88
UniProtKB/Swiss-Prot
Q6WNQ9, C81E9_MEDTR

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