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ENZYME entry: EC 1.14.14.94

Accepted Name
Leukotriene-B(4) 20-monooxygenase.
Alternative Name(s)
CYP4F2.
CYP4F3.
Leucotriene-B(4) omega-hydroxylase.
Leukotriene-B(4) 20-hydroxylase.
LTB4 20-hydroxylase.
LTB4 omega-hydroxylase.
Reaction catalysed
(6Z,8E,10E,14Z)-(5S,12R)-5,12-dihydroxyicosa-6,8,10,14-tetraenoate + [reduced NADPH--hemoprotein reductase] + O(2) <=> (6Z,8E,10E,14Z)-(5S,12R)-5,12,20-trihydroxyicosa-6,8,10,14-tetraenoate + [oxidized NADPH--hemoprotein reductase] + H(2)O
Cofactor(s)
Heme-thiolate.
Comment(s)
  • A cytochrome P450 (heme-thiolate) protein found in mammals.
  • Formerly EC 1.14.13.30.
Cross-references
PROSITEPDOC00081
BRENDA1.14.14.94
EC2PDB1.14.14.94
ExplorEnz1.14.14.94
PRIAM enzyme-specific profiles1.14.14.94
KEGG Ligand Database for Enzyme Nomenclature1.14.14.94
IUBMB Enzyme Nomenclature1.14.14.94
IntEnz1.14.14.94
MEDLINEFind literature relating to 1.14.14.94
MetaCyc1.14.14.94
Rhea expert-curated reactions1.14.14.94
UniProtKB/Swiss-Prot
P33274, CP4F1_RAT;  P78329, CP4F2_HUMAN;  Q08477, CP4F3_HUMAN;  
P51869, CP4F4_RAT;  Q9EP75, CP4FE_MOUSE;  

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