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ENZYME

ENZYME entry: EC 1.14.14.97

PURL: https://purl.expasy.org/enzyme/EC/1.14.14.97
Accepted Name
methyltetrahydroprotoberberine 14-monooxygenase
Alternative Name(s)
(S)-cis-N-methyltetrahydroprotoberberine-14-hydroxylase
CYP82N4
methyltetrahydroprotoberberine 14-hydroxylase
Reaction catalysed
  • (S)-cis-N-methylcanadine + reduced [NADPH--hemoprotein reductase] + O2 = allocryptopine + oxidized [NADPH--hemoprotein reductase] + H2O + 2 H(+)
  • (S)-cis-N-methylstylopine + reduced [NADPH--hemoprotein reductase] + O2 = protopine + oxidized [NADPH--hemoprotein reductase] + H2O + 2 H(+)
Comment(s)
  • A cytochrome P450 (heme-thiolate) protein involved in the biosynthesis of isoquinoline alkaloids in plants.
  • It also hydroxylates (S)-cis-N-methyltetrahydrothalifendine, and (S)- cis-N-methyltetrahydropalmatine.
  • Formerly EC 1.14.13.37.
Cross-references
BRENDA1.14.14.97
EC2PDB1.14.14.97
ExplorEnz1.14.14.97
KEGG Ligand Database for Enzyme Nomenclature1.14.14.97
IUBMB Enzyme Nomenclature1.14.14.97
MEDLINEFind literature relating to 1.14.14.97
MetaCyc1.14.14.97
Rhea expert-curated reactions1.14.14.97
UniProtKB/Swiss-Prot
L7X3S1, MSH_PAPSO

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