ID 1.14.15.15 DE Cholestanetriol 26-monooxygenase. AN 5-beta-cholestane-3-alpha,7-alpha,12-alpha-triol 26-hydroxylase. AN 5-beta-cholestane-3-alpha,7-alpha,12-alpha-triol hydroxylase. AN Cholestanetriol 26-hydroxylase. AN Cholesterol 27-hydroxylase. AN Cytochrome P450 27A1'. AN Sterol 26-hydroxylase. AN Sterol 27-hydroxylase. AN Vitamin D(3) 25-hydroxylase. CA 5-beta-cholestane-3-alpha,7-alpha,12-alpha-triol + 6 reduced adrenodoxin CA + 6 H(+) + 3 O(2) = (25R)-3-alpha,7-alpha,12-alpha-trihydroxy-5-beta- CA cholestan-26-oate + 6 oxidized adrenodoxin + 4 H(2)O. CF Heme-thiolate. CC -!- Catalyzes the first three sterol side chain oxidations in bile acid CC biosynthesis via the neutral (classic) pathway. CC -!- Can also act on cholesterol, cholest-5-en-3-beta,7-alpha-diol, CC 7-alpha-hydroxycholest-4-en-3-one, and 5-beta-cholestane-3-alpha,7- CC alpha-diol. CC -!- The enzyme can also hydroxylate cholesterol at positions 24 and 25. CC -!- The initial source of the electrons is NADPH, which transfers the CC electrons to the adrenodoxin via EC 1.18.1.6. CC -!- Formerly EC 1.14.13.15. PR PROSITE; PDOC00081; DR Q02318, CP27A_HUMAN; Q9DBG1, CP27A_MOUSE; P17177, CP27A_RABIT; DR P17178, CP27A_RAT ; C4B644, CPVDH_PSEAH; //