ID 1.14.15.15
DE Cholestanetriol 26-monooxygenase.
AN 5-beta-cholestane-3-alpha,7-alpha,12-alpha-triol 26-hydroxylase.
AN 5-beta-cholestane-3-alpha,7-alpha,12-alpha-triol hydroxylase.
AN Cholestanetriol 26-hydroxylase.
AN Cholesterol 27-hydroxylase.
AN Cytochrome P450 27A1'.
AN Sterol 26-hydroxylase.
AN Sterol 27-hydroxylase.
AN Vitamin D(3) 25-hydroxylase.
CA 5-beta-cholestane-3-alpha,7-alpha,12-alpha-triol + 6 reduced adrenodoxin
CA + 6 H(+) + 3 O(2) = (25R)-3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-
CA cholestan-26-oate + 6 oxidized adrenodoxin + 4 H(2)O.
CF Heme-thiolate.
CC -!- Catalyzes the first three sterol side chain oxidations in bile acid
CC biosynthesis via the neutral (classic) pathway.
CC -!- Can also act on cholesterol, cholest-5-en-3-beta,7-alpha-diol,
CC 7-alpha-hydroxycholest-4-en-3-one, and 5-beta-cholestane-3-alpha,7-
CC alpha-diol.
CC -!- The enzyme can also hydroxylate cholesterol at positions 24 and 25.
CC -!- The initial source of the electrons is NADPH, which transfers the
CC electrons to the adrenodoxin via EC 1.18.1.6.
CC -!- Formerly EC 1.14.13.15.
PR PROSITE; PDOC00081;
DR Q02318, CP27A_HUMAN; Q9DBG1, CP27A_MOUSE; P17177, CP27A_RABIT;
DR P17178, CP27A_RAT ; O46658, CP2DP_PIG ; C4B644, CPVDH_PSEAH;
DR H2KYS3, DAF9_CAEEL ;
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