ID   1.14.15.15
DE   Cholestanetriol 26-monooxygenase.
AN   5-beta-cholestane-3-alpha,7-alpha,12-alpha-triol 26-hydroxylase.
AN   5-beta-cholestane-3-alpha,7-alpha,12-alpha-triol hydroxylase.
AN   Cholestanetriol 26-hydroxylase.
AN   Cholesterol 27-hydroxylase.
AN   Cytochrome P450 27A1'.
AN   Sterol 26-hydroxylase.
AN   Sterol 27-hydroxylase.
AN   Vitamin D(3) 25-hydroxylase.
CA   5-beta-cholestane-3-alpha,7-alpha,12-alpha-triol + 6 reduced adrenodoxin
CA   + 6 H(+) + 3 O(2) = (25R)-3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-
CA   cholestan-26-oate + 6 oxidized adrenodoxin + 4 H(2)O.
CF   Heme-thiolate.
CC   -!- Catalyzes the first three sterol side chain oxidations in bile acid
CC       biosynthesis via the neutral (classic) pathway.
CC   -!- Can also act on cholesterol, cholest-5-en-3-beta,7-alpha-diol,
CC       7-alpha-hydroxycholest-4-en-3-one, and 5-beta-cholestane-3-alpha,7-
CC       alpha-diol.
CC   -!- The enzyme can also hydroxylate cholesterol at positions 24 and 25.
CC   -!- The initial source of the electrons is NADPH, which transfers the
CC       electrons to the adrenodoxin via EC 1.18.1.6.
CC   -!- Formerly EC 1.14.13.15.
PR   PROSITE; PDOC00081;
DR   Q02318, CP27A_HUMAN;  Q9DBG1, CP27A_MOUSE;  P17177, CP27A_RABIT;
DR   P17178, CP27A_RAT  ;  C4B644, CPVDH_PSEAH;
//