ID   1.14.15.15
DE   cholestanetriol 26-monooxygenase.
AN   5beta-cholestane-3alpha,7alpha,12alpha-triol 26-hydroxylase.
AN   5beta-cholestane-3alpha,7alpha,12alpha-triol hydroxylase.
AN   cholestanetriol 26-hydroxylase.
AN   cholesterol 27-hydroxylase.
AN   cytochrome P450 27A1'.
AN   sterol 26-hydroxylase.
AN   sterol 27-hydroxylase.
AN   vitamin D3 25-hydroxylase.
CA   5beta-cholestane-3alpha,7alpha,12alpha-triol + 5 H(+) + 3 O2 + 6 reduced
CA   [adrenodoxin] = (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-
CA   26-oate + 4 H2O + 6 oxidized [adrenodoxin].
CC   -!- Catalyzes the first three sterol side chain oxidations in bile acid
CC       biosynthesis via the neutral (classic) pathway.
CC   -!- Can also act on cholesterol, cholest-5-en-3beta,7alpha-diol, 7alpha-
CC       hydroxycholest-4-en-3-one, and 5beta-cholestane-3alpha,7alpha-diol.
CC   -!- The enzyme can also hydroxylate cholesterol at positions 24 and 25.
CC   -!- The initial source of the electrons is NADPH, which transfers the
CC       electrons to the adrenodoxin via EC 1.18.1.6.
CC   -!- Formerly EC 1.14.13.15.
DR   Q02318, CP27A_HUMAN;  Q9DBG1, CP27A_MOUSE;  P17177, CP27A_RABIT;
DR   P17178, CP27A_RAT  ;  C4B644, CPVDH_PSEAH;
//