ID   1.14.15.16
DE   vitamin D3 24-hydroxylase.
AN   CYP24A1.
CA   (1) calcitriol + 2 H(+) + O2 + 2 reduced [adrenodoxin] = calcitetrol +
CA   H2O + 2 oxidized [adrenodoxin].
CA   (2) calcidiol + 2 H(+) + O2 + 2 reduced [adrenodoxin] = H2O + 2 oxidized
CA   [adrenodoxin] + secalciferol.
CC   -!- The enzyme can perform up to 6 rounds of hydroxylation of the
CC       substrate calcitriol leading to calcitroic acid.
CC   -!- The human enzyme also shows 23-hydroxylating activity leading to 1,25
CC       dihydroxyvitamin D3-26,23-lactone as end product while the mouse and
CC       rat enzymes do not.
CC   -!- The initial source of the electrons is NADPH, which transfers the
CC       electrons to the adrenodoxin via EC 1.18.1.6.
CC   -!- Formerly EC 1.14.13.126 and EC 1.14.13.n4.
DR   Q07973, CP24A_HUMAN;  Q64441, CP24A_MOUSE;  Q09128, CP24A_RAT  ;
//