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A new class EC 7, Translocases, has been added to the EC list. It will be part of ENZYME from release 2018_10. Read more about EC 7 here.

ENZYME entry: EC 1.14.15.18

Accepted Name
Calcidiol 1-monooxygenase.
Alternative Name(s)
25-hydroxycholecalciferol 1-hydroxylase.
25-hydroxycholecalciferol 1-monooxygenase.
25-hydroxyvitamin D(3) 1-alpha-hydroxylase.
25-hydroxyvitamin D-1 alpha hydroxylase.
25-OHD-1 alpha-hydroxylase.
Reaction catalysed
  • Calcidiol + 2 reduced adrenodoxin + 2 H(+) + O(2) <=> calcitriol + 2 oxidized adrenodoxin + H(2)O
  • Secalciferol + 2 reduced adrenodoxin + 2 H(+) + O(2) <=> calcitetrol + 2 oxidized adrenodoxin + H(2)O
Cofactor(s)
Heme-thiolate.
Comment(s)
Formerly EC 1.14.13.13.
Cross-references
PROSITEPDOC00081
BRENDA1.14.15.18
EC2PDB1.14.15.18
ExplorEnz1.14.15.18
PRIAM enzyme-specific profiles1.14.15.18
KEGG Ligand Database for Enzyme Nomenclature1.14.15.18
IUBMB Enzyme Nomenclature1.14.15.18
IntEnz1.14.15.18
MEDLINEFind literature relating to 1.14.15.18
MetaCyc1.14.15.18
UniProtKB/Swiss-Prot
O15528, CP27B_HUMAN;  O35084, CP27B_MOUSE;  O35132, CP27B_RAT;  

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.14.15.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.14.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.-.-.-