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ENZYME entry: EC 1.14.15.19

Accepted Name
C-19 steroid 1-alpha-hydroxylase.
Alternative Name(s)
CYP260A1.
Reaction catalysed
Testosterone + 2 reduced ferredoxin [iron-sulfur] cluster + O(2) + 2 H(+) <=> 1-alpha-hydroxytestosterone + H(2)O + 2 oxidized ferredoxin [iron-sulfur] cluster
Comment(s)
  • The enzyme, characterized from the bacterium Sorangium cellulosum, is a class I cytochrome P450, and uses ferredoxin as its electron donor.
  • It was shown to act on several C-19 steroid substrates, including testosterone, androstenedione, testosterone-acetate and 11-oxoandrostenedione.
Cross-references
BRENDA1.14.15.19
EC2PDB1.14.15.19
ExplorEnz1.14.15.19
PRIAM enzyme-specific profiles1.14.15.19
KEGG Ligand Database for Enzyme Nomenclature1.14.15.19
IUBMB Enzyme Nomenclature1.14.15.19
IntEnz1.14.15.19
MEDLINEFind literature relating to 1.14.15.19
MetaCyc1.14.15.19

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