ENZYME entry: EC 1.14.15.19
| Accepted Name |
|---|
| C-19 steroid 1-alpha-hydroxylase.
|
| Alternative Name(s) |
|---|
| CYP260A1. |
| Reaction catalysed |
|---|
| Testosterone + 2 reduced ferredoxin [iron-sulfur] cluster + O(2) + 2 H(+) <=> 1-alpha-hydroxytestosterone + H(2)O + 2 oxidized ferredoxin [iron-sulfur] cluster |
| Comment(s) |
|---|
- The enzyme, characterized from the bacterium Sorangium cellulosum,
is a class I cytochrome P450, and uses ferredoxin as its electron
donor.
- It was shown to act on several C-19 steroid substrates, including
testosterone, androstenedione, testosterone-acetate and
11-oxoandrostenedione.
|
| Cross-references |
|---|
| BRENDA | 1.14.15.19 |
| EC2PDB | 1.14.15.19 |
| ExplorEnz | 1.14.15.19 |
| PRIAM enzyme-specific profiles | 1.14.15.19 |
| KEGG Ligand Database for Enzyme Nomenclature | 1.14.15.19 |
| IUBMB Enzyme Nomenclature | 1.14.15.19 |
| IntEnz | 1.14.15.19 |
| MEDLINE | Find literature relating to 1.14.15.19 |
| MetaCyc | 1.14.15.19 |
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