ID   1.14.15.33
DE   pikromycin synthase.
AN   CYP107L1.
CA   (1) 2 H(+) + narbomycin + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = H2O +
CA   2 oxidized [2Fe-2S]-[ferredoxin] + pikromycin.
CA   (2) 2 H(+) + narbomycin + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = H2O +
CA   neopikromycin + 2 oxidized [2Fe-2S]-[ferredoxin].
CA   (3) 4 H(+) + narbomycin + 2 O2 + 4 reduced [2Fe-2S]-[ferredoxin] = 2 H2O
CA   + novapikromycin + 4 oxidized [2Fe-2S]-[ferredoxin].
CA   (4) 10-deoxymethymycin + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] =
CA   H2O + methymycin + 2 oxidized [2Fe-2S]-[ferredoxin].
CA   (5) 10-deoxymethymycin + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] =
CA   H2O + neomethymycin + 2 oxidized [2Fe-2S]-[ferredoxin].
CA   (6) 10-deoxymethymycin + 4 H(+) + 2 O2 + 4 reduced [2Fe-2S]-[ferredoxin]
CA   = 2 H2O + novamethymycin + 4 oxidized [2Fe-2S]-[ferredoxin].
CC   -!- A cytochrome P450 (heme-thiolate) protein.
CC   -!- Involved in the biosynthesis of a number of bacterial macrolide
CC       antibiotics containing a desosamine glycoside unit.
CC   -!- With narbomycin it hydroxylates at either C-12 to give pikromycin or
CC       C-14 to give neopikromycin or both positions to give narvopikromycin.
CC   -!- With 10-deoxymethymycin it hydroxylates at either C-10 to give
CC       methymycin or C-12 to give neomethymycin or both positions to give
CC       novamethymycin.
CC   -!- Formerly EC 1.14.13.185.
DR   O87605, PIKC_STRVZ ;
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