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ENZYME

ENZYME entry: EC 1.14.15.38

Accepted Name
N,N-dimethyl phenylurea N-demethylase
Reaction catalysed
a 1,1-dimethyl-3-phenylurea + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> a 1-methyl-3-phenylurea + formaldehyde + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]
Comment(s)
  • The enzyme, found in members of the Sphingobium genus, initiates the degradation of N,N-dimethyl-phenylurea herbicides by mono-N- demethylation.
  • The catalytic unit contains a Rieske [2Fe-2S] iron-sulfur cluster, and catalyzes the monooxygenation of a methyl group.
  • The resulting N-methoxyl group is unstable and decomposes spontaneously to form formaldehyde.
  • The enzyme associates with additional proteins (a reductase and a [3Fe-4S] type ferredoxin) that are involved in the transfer of electrons from NAD(P)H to the active site.
Cross-references
BRENDA1.14.15.38
EC2PDB1.14.15.38
ExplorEnz1.14.15.38
PRIAM enzyme-specific profiles1.14.15.38
KEGG Ligand Database for Enzyme Nomenclature1.14.15.38
IUBMB Enzyme Nomenclature1.14.15.38
IntEnz1.14.15.38
MEDLINEFind literature relating to 1.14.15.38
MetaCyc1.14.15.38
Rhea expert-curated reactions1.14.15.38
UniProtKB/Swiss-Prot
S5RR11, PDMA_SPHYBS5SC42, PDMB_SPHYB

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