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ENZYME entry: EC 1.14.15.39

Accepted Name
Epi-isozizaene 5-monooxygenase.
Alternative Name(s)
CYP170A1.
Reaction catalysed
(+)-epi-isozizaene + 4 reduced [2Fe-2S] ferredoxin + 4 H(+) + 2 O(2) <=> albaflavenone + 4 oxidized [2Fe-2S] ferredoxin + 3 H(2)O
Comment(s)
  • This enzyme, from the soil-dwelling bacterium Streptomyces coelicolor A3(2), catalyzes two sequential allylic oxidation reactions.
  • The substrate epi-isozizaene, which is formed by the action of EC 4.2.3.37 is first oxidized to yield the epimeric intermediates (5R)-albaflavenol and (5S)-albaflavenol, which can be further oxidized to yield the sesquiterpenoid antibiotic albaflavenone.
  • Formerly EC 1.14.13.106.
Cross-references
BRENDA1.14.15.39
EC2PDB1.14.15.39
ExplorEnz1.14.15.39
PRIAM enzyme-specific profiles1.14.15.39
KEGG Ligand Database for Enzyme Nomenclature1.14.15.39
IUBMB Enzyme Nomenclature1.14.15.39
IntEnz1.14.15.39
MEDLINEFind literature relating to 1.14.15.39
MetaCyc1.14.15.39
Rhea expert-curated reactions1.14.15.39
UniProtKB/Swiss-Prot
Q9K498, EIZFM_STRCO

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