A new class EC 7, Translocases, has been added to the EC list. It will be part of ENZYME from release 2018_10. Read more about EC 7 here.
ENZYME entry: EC 1.14.15.4
| Accepted Name |
|---|
| Steroid 11-beta-monooxygenase.
|
| Alternative Name(s) |
|---|
| Cytochrome p450 XIB1. |
| Steroid 11-beta-hydroxylase. |
| Steroid 11-beta/18-hydroxylase. |
| Reaction catalysed |
|---|
| A steroid + 2 reduced adrenodoxin + O(2) + 2 H(+) <=> an 11-beta-hydroxysteroid + 2 oxidized adrenodoxin + H(2)O |
| Cofactor(s) |
|---|
| Heme-thiolate.
|
| Comment(s) |
|---|
- Also hydroxylates steroids at the 18-position, and converts
18-hydroxycorticosterone into aldosterone.
- Formerly EC 1.14.1.6 and EC 1.99.1.7.
|
| Cross-references |
|---|
| PROSITE | PDOC00081 |
| BRENDA | 1.14.15.4 |
| EC2PDB | 1.14.15.4 |
| ExplorEnz | 1.14.15.4 |
| PRIAM enzyme-specific profiles | 1.14.15.4 |
| KEGG Ligand Database for Enzyme Nomenclature | 1.14.15.4 |
| IUBMB Enzyme Nomenclature | 1.14.15.4 |
| IntEnz | 1.14.15.4 |
| MEDLINE | Find literature relating to 1.14.15.4 |
| MetaCyc | 1.14.15.4 |
| UniProtKB/Swiss-Prot |
| P15150, C11B1_BOVIN; | Q64408, C11B1_CAVPO; | P15538, C11B1_HUMAN; |
| P97720, C11B1_MESAU; | Q29527, C11B1_PAPHU; | Q29552, C11B1_PIG; |
| P15393, C11B1_RAT; | P51663, C11B1_SHEEP; | P19099, C11B2_HUMAN; |
| Q64658, C11B2_MESAU; | P15539, C11B2_MOUSE; | P30099, C11B2_RAT; |
| P30100, C11B3_RAT; | Q92104, CP11B_LITCT; |
|
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