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ENZYME entry: EC 1.14.15.4

Accepted Name
Steroid 11-beta-monooxygenase.
Alternative Name(s)
Cytochrome p450 XIB1.
Steroid 11-beta-hydroxylase.
Steroid 11-beta/18-hydroxylase.
Reaction catalysed
A steroid + 2 reduced adrenodoxin + O(2) + 2 H(+) <=> an 11-beta-hydroxysteroid + 2 oxidized adrenodoxin + H(2)O
Cofactor(s)
Heme-thiolate.
Comment(s)
  • Also hydroxylates steroids at the 18-position, and converts 18-hydroxycorticosterone into aldosterone.
  • Formerly EC 1.14.1.6 and EC 1.99.1.7.
Cross-references
PROSITEPDOC00081
BRENDA1.14.15.4
EC2PDB1.14.15.4
ExplorEnz1.14.15.4
PRIAM enzyme-specific profiles1.14.15.4
KEGG Ligand Database for Enzyme Nomenclature1.14.15.4
IUBMB Enzyme Nomenclature1.14.15.4
IntEnz1.14.15.4
MEDLINEFind literature relating to 1.14.15.4
MetaCyc1.14.15.4
Rhea expert-curated reactions1.14.15.4
UniProtKB/Swiss-Prot
P15150, C11B1_BOVIN;  Q64408, C11B1_CAVPO;  P15538, C11B1_HUMAN;  
P97720, C11B1_MESAU;  Q29527, C11B1_PAPHU;  Q29552, C11B1_PIG;  
P15393, C11B1_RAT;  P51663, C11B1_SHEEP;  P19099, C11B2_HUMAN;  
Q64658, C11B2_MESAU;  P15539, C11B2_MOUSE;  P30099, C11B2_RAT;  
P30100, C11B3_RAT;  Q92104, CP11B_LITCT;  

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