Expasy logo

ENZYME

ENZYME entry: EC 1.14.15.41

PURL: https://purl.expasy.org/enzyme/EC/1.14.15.41
Accepted Name
L-tryptophan 4-nitrase
Alternative Name(s)
4-nitro-L-tryptophane synthase
Reaction catalysed
nitric oxide + L-tryptophan + reduced [2Fe-2S]-[ferredoxin] + O2 + H(+) = 4-nitro-L-tryptophan zwitterion + oxidized [2Fe-2S]-[ferredoxin] + H2O
Comment(s)
  • A cytochrome P450 (heme-thiolate) enzyme characterized from the bacterium Streptomyces turgidiscabies.
  • The enzyme participates in biosynthesis of thaxtomins, cyclic dipeptides formed from the condensation of 4-nitro-L-tryptophan and L-phenylalanine that have phytotoxic properties.
  • The enzyme requires ferredoxin as its electron donor and catalyzes a reaction in which nitric oxide is oxidized to a nitro group and inserted into L-tryptophan at the 4 position (not necessarily in this order).
Cross-references
Rhea expert-curated reactions1.14.15.41
ExplorEnz1.14.15.41
IUBMB Enzyme Nomenclature1.14.15.41
UniProtKB/Swiss-Prot
C9ZDC6, TXTE_STRSWL7F3F8, TXTE_STRT8
BRENDA1.14.15.41
MetaCyc1.14.15.41
KEGG Ligand Database for Enzyme Nomenclature1.14.15.41
MEDLINEFind literature relating to 1.14.15.41

View entry in original ENZYME format
View entry in raw text format (no links)
All UniProtKB/Swiss-Prot entries referenced in this entry, with possibility to download in different formats, align etc.
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.14.15.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.14.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.-.-.-