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ENZYME

ENZYME entry: EC 1.14.15.45

PURL: https://purl.expasy.org/enzyme/EC/1.14.15.45
Accepted Name
4-hydroxy-3-polyprenylbenzoate 5-hydroxylase
Reaction catalysed
a 4-hydroxy-3-(all-trans-polyprenyl)benzoate + 2 reduced [2Fe-2S]-[ferredoxin] + O2 + 2 H(+) = a 3,4-dihydroxy-5-(all-trans-polyprenyl)benzoate + 2 oxidized [2Fe-2S]-[ferredoxin] + H2O
Comment(s)
  • The enzyme, found in eukaryotes, is involved in the biosynthesis of ubiquinone.
  • The vertebrate enzyme catalyzes two hydroxylations in the pathway at the positions meta to the prenyl side chain (the other hydroxylation is classified as EC 1.14.15.46).
  • The number of isoprenoid subunits in the side chain varies in different species.
  • The enzyme does not have any specificity concerning the length of the polyprenyl tail, and accepts tails of various lengths with similar efficiency.
Cross-references
BRENDA1.14.15.45
EC2PDB1.14.15.45
ExplorEnz1.14.15.45
KEGG Ligand Database for Enzyme Nomenclature1.14.15.45
IUBMB Enzyme Nomenclature1.14.15.45
MEDLINEFind literature relating to 1.14.15.45
MetaCyc1.14.15.45
Rhea expert-curated reactions1.14.15.45
UniProtKB/Swiss-Prot
Q2KIL4, COQ6_BOVINO01884, COQ6_CAEELF1RAX8, COQ6_DANRE
Q54EN1, COQ6_DICDIQ9VMQ5, COQ6_DROMEQ9Y2Z9, COQ6_HUMAN
Q8R1S0, COQ6_MOUSEQ68FU7, COQ6_RATQ9Y7Z9, COQ6_SCHPO
Q6DF46, COQ6_XENTRP53318, COQ6_YEAST

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