ID 1.14.15.6 DE cholesterol monooxygenase (side-chain-cleaving). AN cholesterol 20-22-desmolase. AN cholesterol C20-22 desmolase. AN cholesterol desmolase. AN cholesterol side-chain cleavage enzyme. AN cholesterol side-chain-cleaving enzyme. AN CYP11A1. AN cytochrome p450scc. AN cytochrome P-450scc. AN steroid 20-22 desmolase. AN steroid 20-22-lyase. CA cholesterol + 6 H(+) + 3 O2 + 6 reduced [adrenodoxin] = 4-methylpentanal CA + 4 H2O + 6 oxidized [adrenodoxin] + pregnenolone. CC -!- The reaction proceeds in three stages, with two hydroxylations at CC C-22 and C-20 preceding scission of the side-chain between carbons 20 CC and 22. CC -!- The initial source of the electrons is NADPH, which transfers the CC electrons to the adrenodoxin via EC 1.18.1.6. DR P00189, CP11A_BOVIN; P79153, CP11A_CAPHI; O46515, CP11A_HORSE; DR P05108, CP11A_HUMAN; Q92045, CP11A_HYPAM; Q2XV99, CP11A_MACFA; DR Q9EPT4, CP11A_MESAU; Q9QZ82, CP11A_MOUSE; Q07217, CP11A_ONCMY; DR P10612, CP11A_PIG ; Q28827, CP11A_RABIT; P14137, CP11A_RAT ; DR P79202, CP11A_SHEEP; //