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ENZYME entry: EC 1.14.15.8

Accepted Name
steroid 15beta-monooxygenase
Alternative Name(s)
CYP106A2
steroid 15beta-hydroxylase
Reaction catalysed
2 H(+) + O2 + progesterone + reduced 2[4Fe-4S]-[ferredoxin] <=> 15beta-hydroxyprogesterone + H2O + oxidized 2[4Fe-4S]-[ferredoxin]
Comment(s)
  • The enzyme from Bacillus megaterium hydroxylates a variety of 3-oxo- Delta4-steroids in position 15beta.
  • Ring A-reduced, aromatic, and 3beta-hydroxy-Delta4-steroids do not serve as substrates.
Cross-references
BRENDA1.14.15.8
EC2PDB1.14.15.8
ExplorEnz1.14.15.8
PRIAM enzyme-specific profiles1.14.15.8
KEGG Ligand Database for Enzyme Nomenclature1.14.15.8
IUBMB Enzyme Nomenclature1.14.15.8
IntEnz1.14.15.8
MEDLINEFind literature relating to 1.14.15.8
MetaCyc1.14.15.8
Rhea expert-curated reactions1.14.15.8
UniProtKB/Swiss-Prot
Q06069, CPXM_PRIMG

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