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ENZYME entry: EC 1.14.15.8

Accepted Name
Steroid 15-beta-monooxygenase.
Alternative Name(s)
CYP106A2.
Steroid 15-beta-hydroxylase.
Reaction catalysed
Progesterone + 2 reduced [2Fe-2S] ferredoxin + O(2) <=> 15-beta-hydroxyprogesterone + 2 oxidized [2Fe-2S] ferredoxin + H(2)O
Comment(s)
  • The enzyme from Bacillus megaterium hydroxylates a variety of 3-oxo- Delta-4-steroids in position 15-beta.
  • Ring A-reduced, aromatic, and 3-beta-hydroxy-Delta-4-steroids do not serve as substrates.
Cross-references
PROSITEPDOC00081
BRENDA1.14.15.8
EC2PDB1.14.15.8
ExplorEnz1.14.15.8
PRIAM enzyme-specific profiles1.14.15.8
KEGG Ligand Database for Enzyme Nomenclature1.14.15.8
IUBMB Enzyme Nomenclature1.14.15.8
IntEnz1.14.15.8
MEDLINEFind literature relating to 1.14.15.8
MetaCyc1.14.15.8
Rhea expert-curated reactions1.14.15.8
UniProtKB/Swiss-Prot
Q06069, CPXM_BACME

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