Expasy logo

ENZYME

ENZYME entry: EC 1.14.15.8

Accepted Name
steroid 15beta-monooxygenase
Alternative Name(s)
CYP106A2
steroid 15beta-hydroxylase
Reaction catalysed
2 H(+) + O2 + progesterone + reduced 2[4Fe-4S]-[ferredoxin] = 15beta-hydroxyprogesterone + H2O + oxidized 2[4Fe-4S]-[ferredoxin]
Comment(s)
  • The enzyme from Bacillus megaterium hydroxylates a variety of 3-oxo- Delta4-steroids in position 15beta.
  • Ring A-reduced, aromatic, and 3beta-hydroxy-Delta4-steroids do not serve as substrates.
Cross-references
BRENDA1.14.15.8
EC2PDB1.14.15.8
ExplorEnz1.14.15.8
PRIAM enzyme-specific profiles1.14.15.8
KEGG Ligand Database for Enzyme Nomenclature1.14.15.8
IUBMB Enzyme Nomenclature1.14.15.8
IntEnz1.14.15.8
MEDLINEFind literature relating to 1.14.15.8
MetaCyc1.14.15.8
Rhea expert-curated reactions1.14.15.8
UniProtKB/Swiss-Prot
Q06069, CPXM_PRIMG

View entry in original ENZYME format
View entry in raw text format (no links)
All UniProtKB/Swiss-Prot entries referenced in this entry, with possibility to download in different formats, align etc.
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.14.15.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.14.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.-.-.-