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ENZYME entry: EC 1.14.16.5

Accepted Name
Alkylglycerol monooxygenase.
Alternative Name(s)
Glyceryl etherase.
Glyceryl-ether cleaving enzyme.
Glyceryl-ether monooxygenase.
Reaction catalysed
1-alkyl-sn-glycerol + tetrahydrobiopterin + O(2) <=> 1-O-alkyl-sn-glycerol + dihydrobiopterin + H(2)O
Cofactor(s)
Glutathione.
Comment(s)
  • The enzyme cleaves alkylglycerols, but does not cleave alkenylglycerols (plasmalogens).
  • Requires phospholipids for full activity.
  • The product spontaneously breaks down to form a fatty aldehyde and glycerol.
  • Formerly EC 1.14.99.17.
Cross-references
BRENDA1.14.16.5
EC2PDB1.14.16.5
ExplorEnz1.14.16.5
PRIAM enzyme-specific profiles1.14.16.5
KEGG Ligand Database for Enzyme Nomenclature1.14.16.5
IUBMB Enzyme Nomenclature1.14.16.5
IntEnz1.14.16.5
MEDLINEFind literature relating to 1.14.16.5
MetaCyc1.14.16.5
Rhea expert-curated reactions1.14.16.5
UniProtKB/Swiss-Prot
O17554, ALKMO_CAEEL;  Q6NYE4, ALKMO_DANRE;  Q6ZNB7, ALKMO_HUMAN;  
Q8BS35, ALKMO_MOUSE;  A0JPQ8, ALKMO_RAT;  Q5M8F9, ALKMO_XENTR;  

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