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ENZYME entry: EC 1.14.16.5

Accepted Name
alkylglycerol monooxygenase.
Alternative Name(s)
glyceryl etherase.
glyceryl-ether cleaving enzyme.
glyceryl-ether monooxygenase.
Reaction catalysed
(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + 1-O-(1,2-saturated-alkyl)-sn-glycerol + O2 <=> (6R)-L-erythro-6,7-dihydrobiopterin + a 1-(1-hydroxyalkyl)-sn-glycerol + H2O
Comment(s)
  • The enzyme cleaves alkylglycerols, but does not cleave alkenylglycerols (plasmalogens).
  • Requires phospholipids for full activity.
  • The product spontaneously breaks down to form a fatty aldehyde and glycerol.
  • Formerly EC 1.14.99.17.
Cross-references
BRENDA1.14.16.5
EC2PDB1.14.16.5
ExplorEnz1.14.16.5
PRIAM enzyme-specific profiles1.14.16.5
KEGG Ligand Database for Enzyme Nomenclature1.14.16.5
IUBMB Enzyme Nomenclature1.14.16.5
IntEnz1.14.16.5
MEDLINEFind literature relating to 1.14.16.5
MetaCyc1.14.16.5
Rhea expert-curated reactions1.14.16.5
UniProtKB/Swiss-Prot
O17554, ALKMO_CAEEL;  Q6NYE4, ALKMO_DANRE;  Q6ZNB7, ALKMO_HUMAN;  
Q8BS35, ALKMO_MOUSE;  A0JPQ8, ALKMO_RAT;  Q5M8F9, ALKMO_XENTR;  

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