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ENZYME entry: EC 1.14.17.1

Accepted Name
Dopamine beta-monooxygenase.
Alternative Name(s)
(3,4-dihydroxyphenethylamine)-beta-monooxygenase.
Dopamine beta-hydroxylase.
Reaction catalysed
3,4-dihydroxyphenethylamine + 2 ascorbate + O(2) <=> noradrenaline + 2 monodehydroascorbate + H(2)O
Cofactor(s)
Cu cation.
Comment(s)
  • A copper protein.
  • The enzyme, found in animals, binds two copper ions with distinct roles during catalysis.
  • Stimulated by fumarate.
  • Formerly EC 1.14.2.1.
Cross-references
PROSITEPDOC00080
BRENDA1.14.17.1
EC2PDB1.14.17.1
ExplorEnz1.14.17.1
PRIAM enzyme-specific profiles1.14.17.1
KEGG Ligand Database for Enzyme Nomenclature1.14.17.1
IUBMB Enzyme Nomenclature1.14.17.1
IntEnz1.14.17.1
MEDLINEFind literature relating to 1.14.17.1
MetaCyc1.14.17.1
Rhea expert-curated reactions1.14.17.1
UniProtKB/Swiss-Prot
P15101, DOPO_BOVIN;  Q68CI2, DOPO_CANLF;  Q9XTA0, DOPO_HORSE;  
P09172, DOPO_HUMAN;  Q64237, DOPO_MOUSE;  Q05754, DOPO_RAT;  

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