Home  |  Contact

ENZYME entry: EC

Accepted Name
peptidylglycine monooxygenase.
Alternative Name(s)
peptidyl alpha-amidating enzyme.
peptidylglycine 2-hydroxylase.
peptidylglycine alpha-amidating monooxygenase.
Reaction catalysed
a [peptide]-C-terminal glycine + 2 L-ascorbate + O2 <=> a [peptide]-C-terminal (2S)-2-hydroxyglycine + H2O + 2 monodehydro-L-ascorbate radical
  • A copper protein.
  • The enzyme binds two copper ions with distinct roles during catalysis.
  • Peptidylglycines with a neutral amino acid residue in the penultimate position are the best substrates for the enzyme.
  • The product is unstable and dismutates to glyoxylate and the corresponding desglycine peptide amide, a reaction catalyzed by EC
  • In mammals, the two activities are part of a bifunctional protein.
  • Involved in the final step of biosynthesis of alpha-melanotropin and related biologically active peptides.
PRIAM enzyme-specific profiles1.14.17.3
KEGG Ligand Database for Enzyme Nomenclature1.14.17.3
IUBMB Enzyme Nomenclature1.14.17.3
MEDLINEFind literature relating to
Rhea expert-curated reactions1.14.17.3
P08478, AMDA_XENLA;  P12890, AMDB_XENLA;  P83388, AMDL_CAEEL;  
P10731, AMD_BOVIN;  P19021, AMD_HUMAN;  P97467, AMD_MOUSE;  
P14925, AMD_RAT;  Q95XM2, PHM_CAEEL;  O01404, PHM_DROME;  

View entry in original ENZYME format
View entry in raw text format (no links)
All UniProtKB/Swiss-Prot entries referenced in this entry, with possibility to download in different formats, align etc.
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.14.17.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.14.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.-.-.-