ID   1.14.18.12
DE   2-hydroxy fatty acid dioxygenase.
CA   a (2R)-2-hydroxy Cn-fatty acid + O2 = a Cn-1-fatty acid + H2O + CO2.
CC   -!- Requires Fe(II).
CC   -!- The enzyme, characterized from yeast, is involved in phytosphingosine
CC       metabolism.
CC   -!- The reaction is mediated by iron(IV) peroxide and results in the
CC       release of a water molecule and a carbon dioxide molecule, shortening
CC       the substrate by a single carbon atom and forming an odd-numbered
CC       fatty acid.
CC   -!- Both oxygen atoms of the original carboxylate group are released -
CC       one as the leaving water molecule, the other as one of the oxygens of
CC       the carbon dioxide molecule.
CC   -!- The two oxygen atoms in the newly-formed carboxylate originate from
CC       the 2-hydroxy group and from molecular oxygen, respectively.
CC   -!- The other oxygen atom of the molecular oxygen is incorporated into
CC       the leaving CO2 molecule.
CC   -!- The enzyme from the yeast Saccharomyces cerevisiae is active at least
CC       toward C14 to C26 2-hydroxy fatty acids, but not against C8 2-hydroxy
CC       fatty acid.
DR   O13737, MPO1_SCHPO ;  P25338, MPO1_YEAST ;
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