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ENZYME

ENZYME entry: EC 1.14.18.2

PURL: https://purl.expasy.org/enzyme/EC/1.14.18.2
Accepted Name
CMP-N-acetylneuraminate monooxygenase
Alternative Name(s)
CMP-N-acetylneuraminate hydroxylase
CMP-N-acetylneuraminic acid hydroxylase
CMP-Neu5Ac hydroxylase
cytidine monophosphoacetylneuraminate monooxygenase
Reaction catalysed
CMP-N-acetyl-beta-neuraminate + 2 Fe(II)-[cytochrome b5] + O2 + 2 H(+) = CMP-N-glycoloyl-beta-neuraminate + 2 Fe(III)-[cytochrome b5] + H2O
Comment(s)
  • The ferricytochrome b5 produced is reduced by NADH and EC 1.6.2.2.
  • The enzyme can be activated by Fe(2+) or Fe(3+).
  • Formerly EC 1.14.13.45.
Cross-references
BRENDA1.14.18.2
EC2PDB1.14.18.2
ExplorEnz1.14.18.2
KEGG Ligand Database for Enzyme Nomenclature1.14.18.2
IUBMB Enzyme Nomenclature1.14.18.2
MEDLINEFind literature relating to 1.14.18.2
MetaCyc1.14.18.2
Rhea expert-curated reactions1.14.18.2
UniProtKB/Swiss-Prot
Q95V11, CMAH_ASTRUQ9WV23, CMAH_CRIGRQ6GML1, CMAH_DANRE
Q8MJC8, CMAH_GORGOQ9TUJ2, CMAH_MACMUQ61419, CMAH_MOUSE
Q8MJD0, CMAH_PANPAO97598, CMAH_PANTRO19074, CMAH_PIG
Q8MJC6, CMAH_PONPYQ8AVF5, CMAH_XENLA

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