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ENZYME entry: EC

Accepted Name
phosphatidylcholine 12-monooxygenase.
Alternative Name(s)
oleate Delta(12)-hydroxylase.
ricinoleic acid synthase.
Reaction catalysed
1-acyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphocholine + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> 1-acyl-2-[(R)-12-hydroxyoleoyl]-sn-glycero-3-phosphocholine + 2 Fe(III)-[cytochrome b5] + H2O
  • The enzyme, characterized from the plant Ricinus communis (castor bean), is involved in production of the 12-hydroxylated fatty acid ricinoleate.
  • The enzyme requires a cytochrome b5 as the electron donor.
  • Formerly EC
PRIAM enzyme-specific profiles1.14.18.4
KEGG Ligand Database for Enzyme Nomenclature1.14.18.4
IUBMB Enzyme Nomenclature1.14.18.4
MEDLINEFind literature relating to
Rhea expert-curated reactions1.14.18.4
Q41131, FAH12_RICCO

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