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ENZYME

ENZYME entry: EC 1.14.18.7

PURL: https://purl.expasy.org/enzyme/EC/1.14.18.7
Accepted Name
dihydroceramide fatty acyl 2-hydroxylase
Alternative Name(s)
plant sphingolipid fatty acid 2-hydroxylase
Reaction catalysed
an N-(1,2-saturated acyl)sphinganine + 2 Fe(II)-[cytochrome b5] + O2 + 2 H(+) = an N-[(2'R)-hydroxyacyl]sphinganine + 2 Fe(III)-[cytochrome b5] + H2O
Comment(s)
  • The enzyme, characterized from plants, catalyzes the hydroxylation of carbon 2 of long- or very-long-chain fatty acids attached to sphinganine during de novo ceramide synthesis.
  • The enzyme requires an external cytochrome b5 as the electron donor.
  • The newly introduced 2-hydroxyl group has R-configuration. cf. EC 1.14.18.6.
Cross-references
BRENDA1.14.18.7
EC2PDB1.14.18.7
ExplorEnz1.14.18.7
KEGG Ligand Database for Enzyme Nomenclature1.14.18.7
IUBMB Enzyme Nomenclature1.14.18.7
MEDLINEFind literature relating to 1.14.18.7
MetaCyc1.14.18.7
Rhea expert-curated reactions1.14.18.7
UniProtKB/Swiss-Prot
O48916, FAH1_ARATHQ9SUC5, FAH2_ARATHQ03529, SCS7_YEAST

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