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ENZYME

ENZYME entry: EC 1.14.19.12

Accepted Name
acyl-lipid omega-(9-4) desaturase
Alternative Name(s)
acyl-lipid 7-desaturase
acyl-lipid omega-13 desaturase
Reaction catalysed
  • a (9Z,12Z)-octadecadienoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> a (5Z,9Z,12Z)-octadecatrienoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O
  • (9Z,12Z,15Z)-octadecatrienoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> a (5Z,9Z,12Z,15Z)-octadecatetraenoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O
Comment(s)
  • The enzyme, characterized from the green alga Chlamydomonas reinhardtii, is a front-end desaturase that introduces a cis double bond in omega(9) unsaturated C18 or C20 fatty acids incorporated into lipids, at a position 4 carbon atoms from the existing omega(9) bond, toward the carboxy end of the fatty acid (at the omega(13) position).
  • When acting on 20:2Delta(11,14) and 20:3Delta(11,14,17) substrates it introduces the new double bond between carbons 7 and 8.
  • The enzyme contains a cytochrome b5 domain that acts as the direct electron donor for the active site of the desaturase.
Cross-references
BRENDA1.14.19.12
EC2PDB1.14.19.12
ExplorEnz1.14.19.12
PRIAM enzyme-specific profiles1.14.19.12
KEGG Ligand Database for Enzyme Nomenclature1.14.19.12
IUBMB Enzyme Nomenclature1.14.19.12
IntEnz1.14.19.12
MEDLINEFind literature relating to 1.14.19.12
MetaCyc1.14.19.12
Rhea expert-curated reactions1.14.19.12
UniProtKB/Swiss-Prot
Q2HWK7, DES_CHLRE

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