ID   1.14.19.18
DE   sphingolipid 8-(E)-desaturase.
AN   8 fatty acid desaturase.
AN   8-sphingolipid desaturase.
CA   an N-acylsphing-4-enine + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 =
CA   a (4E,8E)-4-sphinga-4,8-dienine ceramide + 2 Fe(III)-[cytochrome b5] +
CA   2 H2O.
CC   -!- The enzyme, characterized from the yeasts Kluyveromyces lactis and
CC       Candida albicans and from the diatom Thalassiosira pseudonana,
CC       introduces a trans double bond at the 8-position of sphingoid bases
CC       in sphingolipids.
CC   -!- The enzyme determines the position of the double bond by its distance
CC       from the alcohol end of the sphingoid base, and contains a cytochrome
CC       b5 domain that acts as the direct electron donor to the active site
CC       of the desaturase.
CC   -!- The homologous enzymes from higher plants, EC 1.14.19.29, act on
CC       phytosphinganine (4-hydroxysphinganine) and produces a mixture of
CC       trans and cis isomers.
DR   C8V7U7, SDEA_EMENI ;  Q5AEK8, SLD1_CANAL ;  Q6CMK7, SLD1_KLULA ;
DR   Q8NKG8, SLD1_KLULC ;  C4QVU3, SLD1_KOMPG ;  Q8NKG9, SLD1_LACK1 ;
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