ID 1.14.19.19 DE sphingolipid 10-desaturase. CA a (4E,8E)-4-sphinga-4,8-dienine ceramide + 2 Fe(II)-[cytochrome b5] + CA 2 H(+) + O2 = 2 Fe(III)-[cytochrome b5] + 2 H2O + N-acyl-(4E,8E,10E)- CA sphingatrienine. CC -!- The enzyme, characterized from the marine diatom Thalassiosira CC pseudonana, produces an all-trans product. CC -!- Similar triunsaturated sphingoid bases are found in some marine CC invertebrates. CC -!- The enzyme determines the position of the double bond by its distance CC from the alcohol end of the sphingoid base, and contains a cytochrome CC b5 domain that acts as the direct electron donor to the active site CC of the desaturase. DR Q4G2T3, DESAT_THAPS; //