ID   1.14.19.21
DE   cholesterol 7-desaturase.
CA   (1) cholesterol + NADPH + O2 + H(+) = 7-dehydrocholesterol + NADP(+) +
CA   2 H2O.
CA   (2) cholesterol + NADH + O2 + H(+) = 7-dehydrocholesterol + NAD(+) +
CA   2 H2O.
CC   -!- The enzyme, characterized from several organisms including the worm
CC       Caenorhabditis elegans, the fly Drosophila melanogaster, and the
CC       ciliate Tetrahymena thermophila, is a Rieske oxygenase.
CC   -!- In insects it participates in the the biosythesis of ecdysteroid
CC       hormones.
CC   -!- The electrons are transferred from NAD(P)H via an electron transfer
CC       chain likely to include ferredoxin reductase and ferredoxin.
CC   -!- The enzyme differs from regular desaturases, such as EC 1.14.19.20,
CC       which are cytochrome b5-dependent and contain the three His-boxes
CC       that are typical to most desaturases.
DR   Q17938, DAF36_CAEEL;  F7J186, NVD1_CIOIN ;  F7J187, NVD2_CIOIN ;
DR   Q1JUZ2, NVD_BOMMO  ;  Q6DHJ3, NVD_DANRE  ;  Q1JUZ1, NVD_DROME  ;
DR   F7J188, NVD_HEMPU  ;  F7J184, NVD_XENLA  ;
//