ID 1.14.19.22 DE acyl-lipid omega-6 desaturase (cytochrome b5). AN linoleate synthase. AN oleate desaturase. AN oleoyl-CoA desaturase. AN phosphatidylcholine desaturase. CA a (9Z)-octadecenoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + CA 2 H(+) + O2 = a (9Z,12Z)-octadecadienoyl-containing glycerolipid + CA 2 Fe(III)-[cytochrome b5] + 2 H2O. CC -!- This microsomal enzyme introduces a cis double bond in fatty acids CC attached to lipid molecules at a location 6 carbons away from the CC methyl end of the fatty acid. CC -!- The distance from the carboxylic acid end of the molecule does not CC affect the location of the new double bond. CC -!- The most common substrates are oleoyl groups attached to either sn-1 CC or sn-2 position of the glycerol backbone in phosphatidylcholine. cf. CC EC 1.14.19.23. CC -!- Formerly EC 1.3.1.35. DR P46313, FAD6E_ARATH; //