ENZYME entry: EC 1.14.19.25
Accepted Name |
Acyl-lipid omega-3 desaturase (cytochrome b5).
|
Reaction catalysed |
A linoleoyl-[glycerolipid] + 2 ferrocytochrome b5 + O(2) + 2 H(+) <=> an alpha-linolenoyl-[glycerolipid] + ferricytochrome b5 + 2 H(2)O |
Comment(s) |
- This microsomal enzyme introduces a cis double bond three carbons
away from the methyl end of a fatty acid incorporated into a
glycerolipid.
- The distance from the carboxylic acid end of the molecule does not
have an effect.
- The plant enzyme acts on carbon 15 of linoleoyl groups incorporated
into both the sn-1 and sn-2 positions of the glycerol backbone of
phosphatidylcholine and other phospholipids, converting them into
alpha-linolenoyl groups.
- The enzyme from the fungus Mortierella alpina acts on gamma-
linolenoyl and arachidonoyl groups, converting them into stearidonoyl
and icosapentaenoyl groups, respectively.
- Cf. EC 1.14.19.35.
|
Cross-references |
BRENDA | 1.14.19.25 |
EC2PDB | 1.14.19.25 |
ExplorEnz | 1.14.19.25 |
PRIAM enzyme-specific profiles | 1.14.19.25 |
KEGG Ligand Database for Enzyme Nomenclature | 1.14.19.25 |
IUBMB Enzyme Nomenclature | 1.14.19.25 |
IntEnz | 1.14.19.25 |
MEDLINE | Find literature relating to 1.14.19.25 |
MetaCyc | 1.14.19.25 |
Rhea expert-curated reactions | 1.14.19.25 |
UniProtKB/Swiss-Prot |
|
View entry in original ENZYME format
View entry in raw text format (no links)
All
ENZYME /
UniProtKB/Swiss-Prot entries corresponding to 1.14.19.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.14.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.-.-.-