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ENZYME entry: EC 1.14.19.25

Accepted Name
Acyl-lipid omega-3 desaturase (cytochrome b5).
Reaction catalysed
A linoleoyl-[glycerolipid] + 2 ferrocytochrome b5 + O(2) + 2 H(+) <=> an alpha-linolenoyl-[glycerolipid] + ferricytochrome b5 + 2 H(2)O
Comment(s)
  • This microsomal enzyme introduces a cis double bond three carbons away from the methyl end of a fatty acid incorporated into a glycerolipid.
  • The distance from the carboxylic acid end of the molecule does not have an effect.
  • The plant enzyme acts on carbon 15 of linoleoyl groups incorporated into both the sn-1 and sn-2 positions of the glycerol backbone of phosphatidylcholine and other phospholipids, converting them into alpha-linolenoyl groups.
  • The enzyme from the fungus Mortierella alpina acts on gamma- linolenoyl and arachidonoyl groups, converting them into stearidonoyl and icosapentaenoyl groups, respectively.
  • Cf. EC 1.14.19.35.
Cross-references
BRENDA1.14.19.25
EC2PDB1.14.19.25
ExplorEnz1.14.19.25
PRIAM enzyme-specific profiles1.14.19.25
KEGG Ligand Database for Enzyme Nomenclature1.14.19.25
IUBMB Enzyme Nomenclature1.14.19.25
IntEnz1.14.19.25
MEDLINEFind literature relating to 1.14.19.25
MetaCyc1.14.19.25
Rhea expert-curated reactions1.14.19.25
UniProtKB/Swiss-Prot
P48623, FAD3E_ARATH;  P48624, FAD3E_BRANA;  Q59J82, FAD3E_MORAP;  

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