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ENZYME entry: EC

Accepted Name
acyl-lipid omega-3 desaturase (cytochrome b5)
Reaction catalysed
a (9Z,12Z)-octadecadienoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> (9Z,12Z,15Z)-octadecatrienoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O
  • This microsomal enzyme introduces a cis double bond three carbons away from the methyl end of a fatty acid incorporated into a glycerolipid.
  • The distance from the carboxylic acid end of the molecule does not have an effect.
  • The plant enzyme acts on carbon 15 of linoleoyl groups incorporated into both the sn-1 and sn-2 positions of the glycerol backbone of phosphatidylcholine and other phospholipids, converting them into alpha-linolenoyl groups.
  • The enzyme from the fungus Mortierella alpina acts on gamma- linolenoyl and arachidonoyl groups, converting them into stearidonoyl and icosapentaenoyl groups, respectively. cf. EC
PRIAM enzyme-specific profiles1.14.19.25
KEGG Ligand Database for Enzyme Nomenclature1.14.19.25
IUBMB Enzyme Nomenclature1.14.19.25
MEDLINEFind literature relating to
Rhea expert-curated reactions1.14.19.25

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