ID   1.14.19.30
DE   acyl-lipid (8-3)-desaturase.
AN   acyl-lipid 5-desaturase.
AN   Delta(5)-fatty-acid desaturase.
CA   (1) an (8Z,11Z,14Z)-icosatrienoyl-containing glycerolipid + 2 Fe(II)-
CA   [cytochrome b5] + 2 H(+) + O2 = (5Z,8Z,11Z,14Z)-eicosatetraenoyl-
CA   containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O.
CA   (2) an (8Z,11Z,14Z,17Z)-eicosatetraenoyl-containing glycerolipid +
CA   2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = a (5Z,8Z,11Z,14Z,17Z)-
CA   eicosapentaenoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] +
CA   2 H2O.
CC   -!- The enzyme, which has been characterized from multiple organisms
CC       including the moss Physcomitrella patens, the marine microalga
CC       Rebecca salina, and the filamentous fungus Mortierella alpina,
CC       introduces a cis double bond at the 5-position in 20-carbon
CC       polyunsaturated fatty acids incorporated in a glycerolipid that
CC       contain a Delta(8) double bond.
CC   -!- The enzyme contains a cytochrome b5 domain that acts as the direct
CC       electron donor to the active site of the desaturase, and does not
CC       require an external cytochrome.
DR   O74212, D5FAD_MORAP;  A9SIZ6, D5FAD_PHYPA;  A4KDP0, D5FAD_REBSA;
DR   Q8S3C1, D5FAD_THRSP;  O96099, FAD5B_DICDI;
//