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ENZYME

ENZYME entry: EC 1.14.19.31

Accepted Name
acyl-lipid (7-3)-desaturase
Alternative Name(s)
acyl-lipid 4-desaturase
Reaction catalysed
  • a (7Z,10Z,13Z,16Z,19Z)-docosapentaenoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = a (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O
  • a (7Z,10Z,13Z,16Z)-docosatetraenoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = a (4Z,7Z,10Z,13Z,16Z)-docosapentaenoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O
Comment(s)
  • The enzymes from several algae introduce a cis double bond at the 4-position in 22-carbon polyunsaturated fatty acids that contain a Delta(7) double bond.
  • The enzyme from the fresh water alga Chlamydomonas reinhardtii acts on the 16 carbon fatty acid (7Z,10Z,13Z)-hexadeca-7,10,13-trienoate.
  • The enzyme contains an N-terminal cytochrome b5 domain that acts as the direct electron donor to the active site of the desaturase, and does not require an external cytochrome.
Cross-references
BRENDA1.14.19.31
EC2PDB1.14.19.31
ExplorEnz1.14.19.31
PRIAM enzyme-specific profiles1.14.19.31
KEGG Ligand Database for Enzyme Nomenclature1.14.19.31
IUBMB Enzyme Nomenclature1.14.19.31
IntEnz1.14.19.31
MEDLINEFind literature relating to 1.14.19.31
MetaCyc1.14.19.31
Rhea expert-curated reactions1.14.19.31
UniProtKB/Swiss-Prot
I2CYZ4, D4FAD_CHLREQ6VPV2, D4FAD_DIALTQ6WNG7, D4FAD_EUGGR
A0PJ29, D4FAD_REBSAQ8S3C0, D4FAD_THRSP

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