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ENZYME entry: EC 1.14.19.33

Accepted Name
Delta(12) acyl-lipid conjugase (11E,13E-forming).
Alternative Name(s)
fatty acid Delta(12)-conjugase.
Reaction catalysed
  • a (9Z,12Z)-octadecadienoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> a (9Z,11E,13E)-octadecatrienoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O
  • (9Z,12Z,15Z)-octadecatrienoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> a (9Z,11E,13E,15Z)-octadecatetraenoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O
Comment(s)
  • The enzyme, characterized from the plants Impatiens balsamina, Momordica charantia (bitter gourd) and Vernicia fordii (tung tree), converts a single cis double bond at carbon 12 to two conjugated trans bonds at positions 11 and 13.
  • The enzyme from Vernicia fordii can also act as a 12(E) desaturase when acting on the monounsaturated fatty acids oleate and palmitoleate.
  • Cf. EC 1.14.19.16.
Cross-references
BRENDA1.14.19.33
EC2PDB1.14.19.33
ExplorEnz1.14.19.33
PRIAM enzyme-specific profiles1.14.19.33
KEGG Ligand Database for Enzyme Nomenclature1.14.19.33
IUBMB Enzyme Nomenclature1.14.19.33
IntEnz1.14.19.33
MEDLINEFind literature relating to 1.14.19.33
MetaCyc1.14.19.33
Rhea expert-curated reactions1.14.19.33
UniProtKB/Swiss-Prot
Q9SP62, FADX_IMPBA;  Q9SP61, FADX_MOMCH;  Q8GZC2, FADX_VERFO;  

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