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ENZYME

ENZYME entry: EC 1.14.19.4

Accepted Name
acyl-lipid (11-3)-desaturase
Alternative Name(s)
acyl-lipid 8-desaturase
Delta(8)-desaturase
SLD
Reaction catalysed
  • an (11Z,14Z)-icosadienoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = an (8Z,11Z,14Z)-icosatrienoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O
  • an (11Z,14Z,17Z)-icosatrienoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = an (8Z,11Z,14Z,17Z)-eicosatetraenoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O
Comment(s)
  • The enzyme, characterized from the protist Euglena gracilis and the microalga Rebecca salina, introduces a cis double bond at the 8-position in 20-carbon fatty acids that are incorporated into a glycerolipid and have an existing Delta(11) desaturation.
  • The enzyme is a front-end desaturase, introducing the new double bond between the pre-existing double bond and the carboxyl-end of the fatty acid.
  • It contains a cytochrome b5 domain that acts as the direct electron donor to the active site of the desaturase, and does not require an external cytochrome.
  • Involved in alternative pathways for the biosynthesis of the polyunsaturated fatty acids arachidonate and icosapentaenoate.
  • Formerly EC 1.14.19.n1.
Cross-references
BRENDA1.14.19.4
EC2PDB1.14.19.4
ExplorEnz1.14.19.4
PRIAM enzyme-specific profiles1.14.19.4
KEGG Ligand Database for Enzyme Nomenclature1.14.19.4
IUBMB Enzyme Nomenclature1.14.19.4
IntEnz1.14.19.4
MEDLINEFind literature relating to 1.14.19.4
MetaCyc1.14.19.4
Rhea expert-curated reactions1.14.19.4
UniProtKB/Swiss-Prot
Q9SWQ9, SLD1_EUGGR

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