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ENZYME

ENZYME entry: EC 1.14.19.41

PURL: https://purl.expasy.org/enzyme/EC/1.14.19.41
Accepted Name
sterol 22-desaturase
Reaction catalysed
5-dehydroepisterol + NADPH + O2 + H(+) = ergosta-5,7,22,24(28)-tetraen-3beta-ol + NADP(+) + 2 H2O
Comment(s)
  • The enzyme, found in yeast and plants, catalyzes the introduction of a double bond between the C-22 and C-23 carbons of certain sterols.
  • In yeast the enzyme acts on ergosta-5,7,24(28)-trien-3beta-ol, a step in the biosynthesis of ergosterol.
  • The enzyme from the plant Arabidopsis thaliana acts on sitosterol and 24-epi-campesterol, producing stigmasterol and brassicasterol, respectively.
Cross-references
BRENDA1.14.19.41
EC2PDB1.14.19.41
ExplorEnz1.14.19.41
KEGG Ligand Database for Enzyme Nomenclature1.14.19.41
IUBMB Enzyme Nomenclature1.14.19.41
MEDLINEFind literature relating to 1.14.19.41
MetaCyc1.14.19.41
Rhea expert-curated reactions1.14.19.41
UniProtKB/Swiss-Prot
O64697, C7101_ARATHO64698, C7102_ARATHQ9ZV29, C7103_ARATH
Q9ZV28, C7104_ARATHQ1T7C2, C7111_SOLLCI1RE80, ERG5A_GIBZE
A0A098DJ84, ERG5B_GIBZEQ4WK25, ERG5_ASPFUG1UB11, ERG5_CANAL
O13820, ERG5_SCHPOP54781, ERG5_YEAST

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