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ENZYME entry: EC 1.14.19.41

Accepted Name
Sterol 22-desaturase.
Reaction catalysed
Ergosta-5,7,24(28)-trien-3-beta-ol + NADPH + O(2) <=> ergosta-5,7,22,24(28)-tetraen-3-beta-ol + NADP(+) + 2 H(2)O
Cofactor(s)
Heme-thiolate.
Comment(s)
  • The enzyme, found in yeast and plants, catalyzes the introduction of a double bond between the C-22 and C-23 carbons of certain sterols.
  • In yeast the enzyme acts on ergosta-5,7,24(28)-trien-3-beta-ol, a step in the biosynthesis of ergosterol.
  • The enzyme from the plant Arabidopsis thaliana acts on sitosterol and 24-epi-campesterol, producing stigmasterol and brassicasterol, respectively.
Cross-references
BRENDA1.14.19.41
EC2PDB1.14.19.41
ExplorEnz1.14.19.41
PRIAM enzyme-specific profiles1.14.19.41
KEGG Ligand Database for Enzyme Nomenclature1.14.19.41
IUBMB Enzyme Nomenclature1.14.19.41
IntEnz1.14.19.41
MEDLINEFind literature relating to 1.14.19.41
MetaCyc1.14.19.41
UniProtKB/Swiss-Prot
O64697, C7101_ARATH;  O64698, C7102_ARATH;  Q9ZV29, C7103_ARATH;  
Q9ZV28, C7104_ARATH;  Q1T7C2, C7111_SOLLC;  P54781, ERG5_YEAST;  

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