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ENZYME entry: EC 1.14.19.46

Accepted Name
sn-1 linoleoyl-lipid 6-desaturase.
Reaction catalysed
A 1-linoleoyl-2-acyl-[glycerolipid] + 2 reduced ferredoxin [iron-sulfur] cluster + O(2) + 2 H(+) <=> a 1-gamma-linolenoyl-2-acyl-[glycerolipid] + 2 oxidized ferredoxin [iron-sulfur] cluster + 2 H(2)O
Comment(s)
  • The enzyme, characterized from cyanobacteria, introduces a cis double bond at carbon 6 of linoleoyl groups (18:2) attached to the sn-1 position of glycerolipids.
  • The enzyme is a front-end desaturase, introducing the new double bond between a pre-existing double bond and the carboxyl-end of the fatty acid.
  • It is nonspecific with respect to the polar head group of the glycerolipid.
Cross-references
BRENDA1.14.19.46
EC2PDB1.14.19.46
ExplorEnz1.14.19.46
PRIAM enzyme-specific profiles1.14.19.46
KEGG Ligand Database for Enzyme Nomenclature1.14.19.46
IUBMB Enzyme Nomenclature1.14.19.46
IntEnz1.14.19.46
MEDLINEFind literature relating to 1.14.19.46
MetaCyc1.14.19.46
Rhea expert-curated reactions1.14.19.46

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