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ENZYME entry: EC 1.14.19.47

Accepted Name
Acyl-lipid (9-3)-desaturase.
Alternative Name(s)
Acyl-lipid 6-desaturase.
Acyl-lipid Delta(6)-desaturase.
Delta(6)-desaturase.
Reaction catalysed
  • An alpha-linolenoyl-[glycerolipid] + 2 ferrocytochrome b5 + O(2) + 2 H(+) <=> a stearidonoyl-[glycerolipid] + ferricytochrome b5 + 2 H(2)O
  • A linoleoyl-[glycerolipid] + 2 ferrocytochrome b5 + O(2) + 2 H(+) <=> a gamma-linolenoyl-[glycerolipid] + ferricytochrome b5 + 2 H(2)O
Comment(s)
  • The enzyme, characterized from the moss Physcomitrella patens and the plant Borago officinalis (borage), introduces a cis double bond at carbon 6 of several acyl-lipids that contain an existing Delta(9) cis double bond.
  • The enzyme contains a cytochrome b5 domain that acts as the electron donor for the active site of the desaturase.
Cross-references
BRENDA1.14.19.47
EC2PDB1.14.19.47
ExplorEnz1.14.19.47
PRIAM enzyme-specific profiles1.14.19.47
KEGG Ligand Database for Enzyme Nomenclature1.14.19.47
IUBMB Enzyme Nomenclature1.14.19.47
IntEnz1.14.19.47
MEDLINEFind literature relating to 1.14.19.47
MetaCyc1.14.19.47
Rhea expert-curated reactions1.14.19.47
UniProtKB/Swiss-Prot
Q9LEN0, ACET6_CERPU;  O04353, DES6_BOROF;  Q9LEM9, DES6_CERPU;  
Q9ZNW2, DES6_PHYPA;  

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