ID   1.14.19.49
DE   tetracycline 7-halogenase.
CA   chloride + FADH2 + O2 + tetracycline = 7-chlorotetracycline + FAD + H(+)
CA   + 2 H2O.
CC   -!- Characterized from the bacterium Streptomyces aureofaciens.
CC   -!- The enzyme forms a lysine chloramine intermediate on an internal
CC       lysine residue before transferring the chlorine to the substrate.
CC   -!- It is stereo-selective for the 4S (natural) isomer of tetracycline.
CC   -!- FADH2 is provided by a dedicated EC 1.5.1.36.
DR   A0A1E7MYN1, CTCP_KITAU ;
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