ENZYME entry: EC 1.14.19.50
Accepted Name |
Noroxomaritidine synthase.
|
Alternative Name(s) |
CYP96T1. |
Reaction catalysed |
- 4'-O-methylnorbelladine + [reduced NADPH--hemoprotein reductase] + O(2) <=> (10bS,4aR)-noroxomaritidine + [oxidized NADPH--hemoprotein reductase] + 2 H(2)O
- 4'-O-methylnorbelladine + [reduced NADPH--hemoprotein reductase] + O(2) <=> (10bR,4aS)-noroxomaritidine + [oxidized NADPH--hemoprotein reductase] + 2 H(2)O
|
Cofactor(s) |
Heme-thiolate.
|
Comment(s) |
- The enzyme, characterized from Narcissus aff pseudonarcissus
(daffodil), forms the two enantiomers of the Amaryllidacea alkaloid
noroxomaritidine by catalyzing intramolecular oxidative para-para'
phenol coupling.
- The oxidation involves molecular oxygen without its incorporation
into the product.
|
Cross-references |
BRENDA | 1.14.19.50 |
EC2PDB | 1.14.19.50 |
ExplorEnz | 1.14.19.50 |
PRIAM enzyme-specific profiles | 1.14.19.50 |
KEGG Ligand Database for Enzyme Nomenclature | 1.14.19.50 |
IUBMB Enzyme Nomenclature | 1.14.19.50 |
IntEnz | 1.14.19.50 |
MEDLINE | Find literature relating to 1.14.19.50 |
MetaCyc | 1.14.19.50 |
Rhea expert-curated reactions | 1.14.19.50 |
UniProtKB/Swiss-Prot |
|
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