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ENZYME entry: EC 1.14.19.50

Accepted Name
Noroxomaritidine synthase.
Alternative Name(s)
CYP96T1.
Reaction catalysed
  • 4'-O-methylnorbelladine + [reduced NADPH--hemoprotein reductase] + O(2) <=> (10bS,4aR)-noroxomaritidine + [oxidized NADPH--hemoprotein reductase] + 2 H(2)O
  • 4'-O-methylnorbelladine + [reduced NADPH--hemoprotein reductase] + O(2) <=> (10bR,4aS)-noroxomaritidine + [oxidized NADPH--hemoprotein reductase] + 2 H(2)O
Cofactor(s)
Heme-thiolate.
Comment(s)
  • The enzyme, characterized from Narcissus aff pseudonarcissus (daffodil), forms the two enantiomers of the Amaryllidacea alkaloid noroxomaritidine by catalyzing intramolecular oxidative para-para' phenol coupling.
  • The oxidation involves molecular oxygen without its incorporation into the product.
Cross-references
BRENDA1.14.19.50
EC2PDB1.14.19.50
ExplorEnz1.14.19.50
PRIAM enzyme-specific profiles1.14.19.50
KEGG Ligand Database for Enzyme Nomenclature1.14.19.50
IUBMB Enzyme Nomenclature1.14.19.50
IntEnz1.14.19.50
MEDLINEFind literature relating to 1.14.19.50
MetaCyc1.14.19.50
Rhea expert-curated reactions1.14.19.50
UniProtKB/Swiss-Prot
A0A140IL90, C96T1_NARAP;  A0A2H5AJ00, C96T1_NARPS;  A0A140IL91, C96T2_NARAP;  
A0A2H5AIZ9, C96T2_NARPS;  A0A140IL92, C96T3_NARAP;  

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