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ENZYME entry: EC 1.14.19.52

Accepted Name
Camalexin synthase.
Alternative Name(s)
Bifunctional dihydrocamalexate synthase/camalexin synthase.
CYP71B15.
Reaction catalysed
2-(L-cystein-S-yl)-2-(1H-indol-3-yl)acetonitrile + 2 [reduced NADPH--hemoprotein reductase] + 2 O(2) <=> camalexin + hydrogen cyanide + CO(2) + 2 [oxidized NADPH--hemoprotein reductase] + 4 H(2)O
Cofactor(s)
Heme-thiolate.
Comment(s)
  • This P450 enzyme, which has been characterized from the plant Arabidopsis thaliana, catalyzes the last two steps in the biosynthesis of camalexin, the main phytoalexin in that plant.
  • The enzyme catalyzes two successive oxidation events.
  • During the first of oxidation the enzyme introduces a C-N double bond, liberating hydrogen cyanide, and during the second oxidation it catalyzes a decarboxylation.
  • Formerly EC 1.3.1.n2.
Cross-references
BRENDA1.14.19.52
EC2PDB1.14.19.52
ExplorEnz1.14.19.52
PRIAM enzyme-specific profiles1.14.19.52
KEGG Ligand Database for Enzyme Nomenclature1.14.19.52
IUBMB Enzyme Nomenclature1.14.19.52
IntEnz1.14.19.52
MEDLINEFind literature relating to 1.14.19.52
MetaCyc1.14.19.52
UniProtKB/Swiss-Prot
Q9LW27, C71BF_ARATH

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