ID   1.14.19.57
DE   1H-pyrrole-2-carbonyl-[peptidyl-carrier protein] brominase.
CA   (1H-pyrrole-2-carbonyl)-[peptidyl-carrier protein] + 3 bromide + 3 FADH2
CA   + 3 O2 = (3,4,5-tribromo-1H-pyrrole-2-carbonyl)-[peptidyl-carrier
CA   protein] + 3 FAD + 6 H2O.
CC   -!- The enzyme, characterized from marine bacteria of the
CC       Pseudoalteromonas genus, belongs to a family of FAD-dependent
CC       halogenases that act on acyl-carrier protein-tethered substrates.
CC   -!- It catalyzes three successive rounds of bromination.
CC   -!- While the order has not been verified, it is believed to resemble
CC       that of EC 1.14.19.56, due to significant sequence homology.
CC   -!- Reduced FAD is provided in situ by a dedicated reductase and diffuses
CC       into the active site, where it reacts with the oxygen and bromide
CC       ion, resulting in formation of a bromoamine intermediate on a
CC       catalytic lysine side chain, and the eventual transfer of the bromide
CC       to the substrate.
CC   -!- The enzyme from Pseudoalteromonas luteoviolacea 2ta16 is specific for
CC       bromide and does not accept chloride.
DR   V4HJ70, BMP2_PSEL2 ;
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