ID   1.14.19.58
DE   tryptophan 5-halogenase.
CA   chloride + FADH2 + L-tryptophan + O2 = 5-chloro-L-tryptophan + FAD +
CA   2 H2O.
CC   -!- A flavin-dependent halogenase.
CC   -!- The enzyme from the bacterium Streptomyces rugosporus catalyzes
CC       halogenation of the C-5 position of tryptophan during the
CC       biosynthesis of the antibiotic compound pyrroindomycin B.
CC   -!- It utilizes molecular oxygen to oxidize the FADH2 cofactor, giving
CC       C4a-hydroperoxyflavin, which then reacts with chloride to produce a
CC       hypochlorite ion.
CC   -!- The latter reacts with an active site lysine to generate a
CC       chloramine, which chlorinates the substrate. cf. EC 1.14.19.9 and
CC       EC 1.14.19.59.
DR   A4D0H5, TRP5H_STRRG;
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