ID   1.14.19.59
DE   tryptophan 6-halogenase.
CA   (1) chloride + FADH2 + L-tryptophan + O2 = 6-chloro-L-tryptophan + FAD +
CA   2 H2O.
CA   (2) chloride + D-tryptophan + FADH2 + O2 = 6-chloro-D-tryptophan + FAD +
CA   2 H2O.
CC   -!- The enzyme is a flavin-dependent halogenase that has been described
CC       from several bacterial species.
CC   -!- It utilizes molecular oxygen to oxidize the FADH2 cofactor, giving
CC       C4a-hydroperoxyflavin, which then reacts with chloride to produce a
CC       hypochlorite ion.
CC   -!- The latter reacts with an active site lysine to generate a
CC       chloramine, which chlorinates the substrate. Cf. EC 1.14.19.9 and
CC       EC 1.14.19.58.
DR   A1E280, TRP6H_STRAO;  E9P162, TRP6H_STRT5;
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