ID 1.14.19.6 DE acyl-CoA (9+3)-desaturase. AN Delta(12)(omega(6))-desaturase. AN Delta(12) desaturase. AN Delta(12) fatty acid desaturase. AN Delta(12)-fatty-acid desaturase. AN oleoyl-CoA 12-desaturase. AN oleoyl-CoA Delta(12) desaturase. CA (1) (9Z)-octadecenoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = CA (9Z,12Z)-octadecadienoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O. CA (2) (9Z)-hexadecenoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = CA (9Z,12Z)-hexadecadienoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O. CC -!- This microsomal enzyme introduces a cis double bond at position 12 of CC fatty-acyl-CoAs that contain a cis double bond at position 9. CC -!- When acting on 19:1Delta(10) fatty acyl-CoA the enzyme from the CC pathogenic protozoan Trypanosoma brucei introduces the new double CC bond at position 13, indicating that the new double bond is CC introduced three carbons from the existing cis double bond, toward CC the methyl-end of the fatty acid. CC -!- Formerly EC 1.14.19.n3. DR B7SB91, FAD12_ACHDO; Q9Y8H5, FAD12_MORAP; P59668, FAD12_MORIS; DR B7SB92, FAD12_TRICA; Q8GZC3, FAD2_VERFO ; P46313, FAD6E_ARATH; DR G5EGA5, FAT2_CAEEL ; //