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ENZYME entry: EC 1.14.19.64

Accepted Name
(S)-stylopine synthase.
Alternative Name(s)
(S)-cheilanthifoline oxidase (methylenedioxy-bridge-forming).
Reaction catalysed
(S)-cheilanthifoline + [reduced NADPH--hemoprotein reductase] + O(2) <=> (S)-stylopine + [oxidized NADPH--hemoprotein reductase] + 2 H(2)O
Cofactor(s)
Heme-thiolate.
Comment(s)
  • A cytochrome P450 (heme-thiolate) protein catalyzing an oxidative reaction that does not incorporate oxygen into the product.
  • Forms the second methylenedioxy bridge of the protoberberine alkaloid stylopine from oxidative ring closure of adjacent phenolic and methoxy groups of cheilanthifoline.
  • Formerly EC 1.1.3.32 and EC 1.14.21.1.
Cross-references
BRENDA1.14.19.64
EC2PDB1.14.19.64
ExplorEnz1.14.19.64
PRIAM enzyme-specific profiles1.14.19.64
KEGG Ligand Database for Enzyme Nomenclature1.14.19.64
IUBMB Enzyme Nomenclature1.14.19.64
IntEnz1.14.19.64
MEDLINEFind literature relating to 1.14.19.64
MetaCyc1.14.19.64
UniProtKB/Swiss-Prot
Q50LH3, C7192_ESCCA;  Q50LH4, C7193_ESCCA;  B1NF19, C719D_ARGME;  

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