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ENZYME entry: EC 1.14.19.66

Accepted Name
Berbamunine synthase.
Alternative Name(s)
(S)-N-methylcoclaurine oxidase (C-O phenol-coupling).
Reaction catalysed
(S)-N-methylcoclaurine + (R)-N-methylcoclaurine + [reduced NADPH--hemoprotein reductase] + O(2) <=> berbamunine + [oxidized NADPH--hemoprotein reductase] + 2 H(2)O
Cofactor(s)
Heme-thiolate.
Comment(s)
  • A cytochrome P450 (heme-thiolate) protein found in plants.
  • Forms the bisbenzylisoquinoline alkaloid berbamunine by phenol oxidation of N-methylcoclaurine without the incorporation of oxygen into the product.
  • Reaction of two molecules of (R)-N-methylcoclaurine gives the dimer guattagaumerine.
  • Formerly EC 1.1.3.34 and EC 1.14.21.3.
Cross-references
PROSITEPDOC00081
BRENDA1.14.19.66
EC2PDB1.14.19.66
ExplorEnz1.14.19.66
PRIAM enzyme-specific profiles1.14.19.66
KEGG Ligand Database for Enzyme Nomenclature1.14.19.66
IUBMB Enzyme Nomenclature1.14.19.66
IntEnz1.14.19.66
MEDLINEFind literature relating to 1.14.19.66
MetaCyc1.14.19.66
UniProtKB/Swiss-Prot
P47195, C80A1_BERST

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