ID   1.14.19.68
DE   (S)-canadine synthase.
AN   (S)-tetrahydroberberine synthase.
AN   (S)-tetrahydrocolumbamine oxidase (methylenedioxy-bridge-forming).
AN   CYP719A.
CA   (S)-tetrahydrocolumbamine + O2 + reduced [NADPH--hemoprotein reductase] =
CA   (S)-canadine + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase].
CC   -!- A cytochrome P450 (heme-thiolate) protein found in plants.
CC   -!- The enzyme catalyzes an oxidative reaction that does not incorporate
CC       oxygen into the product.
CC   -!- Oxidation of the methoxyphenol group of the alkaloid
CC       tetrahydrocolumbamine results in the formation of the methylenedioxy
CC       bridge of canadine.
CC   -!- Formerly EC 1.1.3.36 and EC 1.14.21.5.
DR   Q50LH4, C7193_ESCCA;  Q948Y1, C719A_COPJA;  B1NF19, C719D_ARGME;
DR   I3QBP4, C7A21_PAPSO;
//