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A new class EC 7, Translocases, has been added to the EC list. It will be part of ENZYME from release 2018_10. Read more about EC 7 here.

ENZYME entry: EC 1.14.19.69

Accepted Name
Biflaviolin synthase.
Alternative Name(s)
CYP158A2.
Reaction catalysed
  • 2 flaviolin + 2 reduced ferredoxin [iron-sulfur] cluster + 2 H(+) + O(2) <=> 3,3'-biflaviolin + 2 oxidized ferredoxin [iron-sulfur] cluster + 2 H(2)O
  • 2 flaviolin + 2 reduced ferredoxin [iron-sulfur] cluster + 2 H(+) + O(2) <=> 3,8'-biflaviolin + 2 oxidized ferredoxin [iron-sulfur] cluster + 2 H(2)O
Comment(s)
  • This cytochrome-P450 (heme-thiolate) enzyme, from the soil-dwelling bacterium Streptomyces coelicolor A3(2), catalyzes a phenol oxidation C-C coupling reaction, which results in the polymerization of flaviolin to form biflaviolin or triflaviolin without the incorporation of oxygen into the product.
  • The products are highly conjugated pigments that protect the bacterium from the deleterious effects of UV irradiation.
  • Formerly EC 1.14.21.7.
Cross-references
PROSITEPDOC00081
BRENDA1.14.19.69
EC2PDB1.14.19.69
ExplorEnz1.14.19.69
PRIAM enzyme-specific profiles1.14.19.69
KEGG Ligand Database for Enzyme Nomenclature1.14.19.69
IUBMB Enzyme Nomenclature1.14.19.69
IntEnz1.14.19.69
MEDLINEFind literature relating to 1.14.19.69
MetaCyc1.14.19.69
UniProtKB/Swiss-Prot
Q9KZF5, C1581_STRCO;  Q9FCA6, C1582_STRCO;  

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